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anti trem1  (R&D Systems)


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    R&D Systems anti trem1
    Anti Trem1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+human+trem+1/Human+TREM-1+Antibody/pm41782012-77-25-26
    Average 94 stars, based on 14 article reviews
    anti trem1 - by Bioz Stars, 2026-11
    94/100 stars

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    Related Articles

    Labeling:

    Article Title: Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4.
    Article Snippet: .. Anti-human TREM-1 (clone 193015) and PE-conjugated antihuman TREM-1 (clone 193015-PE labeled) were from R&D Systems (Minneapolis, MN, USA) and are herein indicated as anti-TREM-1 and TREM-1–PE, respectively. .. Anti-phospho ERK1/2, anti-phospho AKT, anti-Lyn, anti-phospho STAT5 and anti-STAT5, anti-TLR4 and irrelevant mouse IgG1 isotype control were from Santa Cruz (Santa Cruz, CA, USA).

    Western Blot:

    Article Title: Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
    Article Snippet: Proper isotype-matched control Abs (Dako North America) were used. .. Abs used for Western blot include: mouse anti–human TREM-1 (R&D Systems), mouse anti–human HIF-1 (BD-Biosciences), rabbit anti–human phospho (p)-ERK)-1, p-Akt, and p-I B (Cell Signaling Technology), mouse anti–human DAP12, rabbit anti–human ERK-1, Akt, IkB , and -actin (Santa Cruz Biotechnology), .. Flow cytometry was performed as described.12,13 Cells resuspended with phosphate-buffered saline supplemented with 0.2% bovine serum albumin, 0.01% NaN3 were incubated with fluorochrome-conjugated mAbs for 30 minutes at 4°C, after blocking nonspecific sites with rabbit IgG (SigmaAldrich).

    other:

    Article Title: TREM-1 Is Induced in Tumor Associated Macrophages by Cyclo-Oxygenase Pathway in Human Non-Small Cell Lung Cancer
    Article Snippet: Cells were transfected with siRNA oligonucleotides targeting human COX-2 mRNA, and a non-related control siRNA (Santa Cruz) through specific LONZA transfection reagents (LONZA) according to the manufacturer’s instructions.



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    Fig. 2 Iluzanebart is a specific agonist of human TREM2. A hTREM1-HEK. In a HEK293T cell line expressing hTREM1 and hDAP12, an <t>anti-TREM1</t> antibody (green) stimulated phosphorylation of SYK after 45-min treatment, whereas iluzanebart (blue) did not (n = 3 independent experiments), confirming that iluzanebart is a TREM2-specific agonist with no cross-reactivity to the related TREM1 receptor. B TREM2 -/- iMGL. Iluzanebart (blue) does not stimulate pSYK in TREM2−/− human iPSC-derived microglia. Concanavalin A (green) was used as a positive control demonstrating that TREM2−/− cells can activate pSYK in response to TREM2-independent activators. Data shown is normalized to IgG control after 5 min exposure (n = 2 independent experiments) and reported as % of maximal activation. C iPSC Derived Human iMGL. Treatment of human iPSC microglia with iluzanebart reduced levels of soluble TREM2 levels after 24 h, compared to IgG control which had no effect (n = 2 independent experiments)
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    Fig. 2 Iluzanebart is a specific agonist of human TREM2. A hTREM1-HEK. In a HEK293T cell line expressing hTREM1 and hDAP12, an <t>anti-TREM1</t> antibody (green) stimulated phosphorylation of SYK after 45-min treatment, whereas iluzanebart (blue) did not (n = 3 independent experiments), confirming that iluzanebart is a TREM2-specific agonist with no cross-reactivity to the related TREM1 receptor. B TREM2 -/- iMGL. Iluzanebart (blue) does not stimulate pSYK in TREM2−/− human iPSC-derived microglia. Concanavalin A (green) was used as a positive control demonstrating that TREM2−/− cells can activate pSYK in response to TREM2-independent activators. Data shown is normalized to IgG control after 5 min exposure (n = 2 independent experiments) and reported as % of maximal activation. C iPSC Derived Human iMGL. Treatment of human iPSC microglia with iluzanebart reduced levels of soluble TREM2 levels after 24 h, compared to IgG control which had no effect (n = 2 independent experiments)
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    Image Search Results


    Fig. 2 Iluzanebart is a specific agonist of human TREM2. A hTREM1-HEK. In a HEK293T cell line expressing hTREM1 and hDAP12, an anti-TREM1 antibody (green) stimulated phosphorylation of SYK after 45-min treatment, whereas iluzanebart (blue) did not (n = 3 independent experiments), confirming that iluzanebart is a TREM2-specific agonist with no cross-reactivity to the related TREM1 receptor. B TREM2 -/- iMGL. Iluzanebart (blue) does not stimulate pSYK in TREM2−/− human iPSC-derived microglia. Concanavalin A (green) was used as a positive control demonstrating that TREM2−/− cells can activate pSYK in response to TREM2-independent activators. Data shown is normalized to IgG control after 5 min exposure (n = 2 independent experiments) and reported as % of maximal activation. C iPSC Derived Human iMGL. Treatment of human iPSC microglia with iluzanebart reduced levels of soluble TREM2 levels after 24 h, compared to IgG control which had no effect (n = 2 independent experiments)

    Journal: Journal of neuroinflammation

    Article Title: Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism.

    doi: 10.1186/s12974-025-03346-1

    Figure Lengend Snippet: Fig. 2 Iluzanebart is a specific agonist of human TREM2. A hTREM1-HEK. In a HEK293T cell line expressing hTREM1 and hDAP12, an anti-TREM1 antibody (green) stimulated phosphorylation of SYK after 45-min treatment, whereas iluzanebart (blue) did not (n = 3 independent experiments), confirming that iluzanebart is a TREM2-specific agonist with no cross-reactivity to the related TREM1 receptor. B TREM2 -/- iMGL. Iluzanebart (blue) does not stimulate pSYK in TREM2−/− human iPSC-derived microglia. Concanavalin A (green) was used as a positive control demonstrating that TREM2−/− cells can activate pSYK in response to TREM2-independent activators. Data shown is normalized to IgG control after 5 min exposure (n = 2 independent experiments) and reported as % of maximal activation. C iPSC Derived Human iMGL. Treatment of human iPSC microglia with iluzanebart reduced levels of soluble TREM2 levels after 24 h, compared to IgG control which had no effect (n = 2 independent experiments)

    Article Snippet: R&D anti-mouse/anti-rat antibody (#MAB17291), R&D Systems] anti-human TREM1 antibody (#MAB1278), Concanavalin A (Sigma, #C2010), PLX5622 (MedChem Express, #50-196-9292), IL4 (Peprotech #200-04).

    Techniques: Expressing, Phospho-proteomics, Derivative Assay, Positive Control, Control, Activation Assay